Scientists in the US have developed a powerful new genome editing system that could offer significantly more precision and efficiency than the current CRISPR standard. 美国科学家已研发出强大的新的基因组编辑系统,显著提高目前CRISPR标准的精度和效率。 While CRISPR-Cas9 is a revolutionary medical technology that lay the modern foundations for editing genetic code – including variants associated with disease – there have long been concerns over its potential for imprecision. 虽然CRISPR-Cas9是革命性的医疗技术,为编辑包括与疾病相关的变异在内的遗传密码奠定了现代基础,但一直存在对其潜在的不精确性的担忧。 Specifically, many fear that CRISPR-Cas9 editing carries the potential to introduce errors in the form of uncontrolled insertions and deletions in genetic code, called indels. 具体来说就是很多人害怕CRISPR-Cas9编辑有可能在被称为索引的遗传密码中不受控制的插入和删除信息从而导致错误。 Researchers say the new system, dubbed 'prime editing' by its inventors at the Broad Institute of MIT and Harvard University, could change the game thanks to a new protein that enables high-precision edits of genetic targets. 研究人员说被麻省理工学院和哈佛大学的布罗德研究所的发明者称为“先导编辑”的这一新系统能改变基因,有一种新型蛋白质使研究人员可以对目标基因进行高精度编辑。 |