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A new study finds that an active lifestyle may help protect against Alzheimer's-related brain changes in people who have a well-known genetic risk factor. This factor is the e4 allele (version) of the apolipoprotein E (APOE) gene. 一项新的研究表明经常运动能帮助那些有老年痴呆症遗传因素的人们降低患病风险。这种遗传因素是载脂蛋白Ee4等位基因。 "The presence of an APOE e4 allele is the most established genetic risk factor for Alzheimer disease, with a higher percentage of individuals with Alzheimer's disease having an e4 allele in comparison with the general population," the authors write in the article published online Jan. 9 in the journal Archives of Neurology. It's been suggested that the presence or absence of this gene variant might affect the relationship "between lifestyle factors such as exercise engagement and risk of cognitive decline and dementia," added researcher Denise Head and colleagues at Washington University, St. Louis. “载脂蛋白e4等位基因的存在是患老年痴呆症的最大潜在威胁，患有老年痴呆症的人群跟普通人群相比，他们体内含有的e4等位基因比例更高。”该研究的作者在《神经学档案》1月9日的电子刊上如此说道，“据研究这种基因的存在与否可能会影响运动量等生活方式和认知功能下降及痴呆之间的关系。”研究员Denise Head及其圣路易华盛顿大学的同事们补充说。 | 
