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[美文] Designing an alternative to antibiotics

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In 1928 a British scientist made a "chance observation." He noticed that some mold had grown in bacteria in a culture plate in his laboratory. Molds can do that. But this mold that had somehow gotten into the plate had the ability to kill the bacteria around it.

The scientist, Alexander Fleming, found that the mold was a member of a common group known as Penicillium. Fleming and two other scientists -- Ernst Boris Chain and Howard Walter Florey -- went on to win the Nobel Prize in 1945. They were honored "for the discovery of penicillin and its curative effect in various infectious diseases."

Other powerful antibiotics have been discovered since penicillin. But many antibiotics have become less and less effective as the germs they are designed to kill develop resistance.

So scientists are searching for new ways to treat infections. Now, researchers in Australia say they have made a important discovery. Scientists at Monash University in Melbourne believe an antibacterial viral protein called PlyC could be used as an alternative to antibiotics.

This protein was first identified as a possible treatment for infections in 1925. But the research ended following the discovery of antibiotics.

Now, scientists have spent six years studying the structure of the protein. They have found how it kills the bacteria that cause sore throats, pneumonia and streptococcal toxic shock syndrome.

Australian researchers worked with scientists at the Rockefeller University in New York and the University of Maryland. Their findings appear in the Proceedings of the National Academy of Sciences.

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