Gene therapy 基因疗法 Genetic mutations predict which cancers willrespond to treatment 基因突变将预测某种治疗会对哪些癌症起作用 THE International Cancer Genome Consortium, analliance of laboratories that is trying to produce adefinitive list of the genetic mutations that causecancer, is accumulating data at an astonishing rate. About 3,000 individual breast tumours,for example, have now had their genotypes published. But these data will not, bythemselves, help patients. For that, they have to be collected in the context of a drug trial.And this is just what Matthew Ellis and his colleagues at Washington University in St Louishave done for women suffering from breast cancer. Their methods, if they prove to work forother cancers too, may revolutionise treatment. 国际癌症基因组协作组是试图建立一份会引起癌症的基因突变完整清单的实验室联盟,它积累数据的速度让人吃惊。例如,它已经发表了大约3000种不同的乳房肿瘤的基因型。但光凭这些数据本身无法帮助患者。要医治病人,人们必须结合药物试验采集数据。而这正是在圣路易斯市的华盛顿大学工作的马修?埃利斯及其同事们为罹患乳腺癌的妇女们所作的工作。如果事实证明他们的方法对其他癌症也有用的话,这可能会是癌症治疗的一次革命。 |