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Late-Night Drinking Coffee lovers beware. Having a quick pick-me-up cup of coffee1 late in the day will play havoc with2 your sleep. As well as being a stimulant, caffeine interrupts the flow of melatonin, the brain hormone that sends people into a sleep. Melatonin levels normally start to rise about two hours before bedtime. Levels then peak between 2 am and 4 am, before falling again3. Its the neurohormone that controls our sleep and tells our body when to sleep and when to wake, says Maurice Ohayon of the Stanford Sleep Epidemiology Research Center at Stanford University in California. But researchers in Israel have found that caffcinated coffee halves the bodys levels of this sleep hormone. Lotan Shilo and a team at the Sapir Medical Center in Tel Aviv University found that six volunteers slept less well after a cup of caffeinated coffee than after drinking the same amount of decal. On average, subjects slept 336 minutes per night after drinking caffeinated coffee, compared with 415 minutes after decal. They also took half an hour to drop off4 - twice as long as usual - and jigged around5 in bed twice as much. In the second phase of the experiment, the researchers woke the volunteers every three hours and asked them to give a urine sample, Shilo measured concentrations of a breakdown product of melatonin. The results suggest that melatonin concentrations in caffeine drinkers were half those in decaf drinkers. In a paper accepted for publication in Sleep Medicine, the researchers suggest6 that caffeine blocks production of the enzyme that drives melatonin production. | 
