某些胃药可能增加心肌梗死的风险
<p><span word="Heartburn">Heartburn</span> <span word="Drugs">Drugs</span> <span word="Linked">Linked</span> <span word="to">to</span> <span word="Heart">Heart</span> <span word="Attacks">Attacks</span></p><p>某些胃药可能增加心肌梗死的风险</p><p><span word="The">The</span> <span word="widely">widely</span> <span word="used">used</span> <span word="drugs">drugs</span> <span word="known">known</span> <span word="as">as</span> <span word="proton">proton</span> <span word="pump">pump</span> <span word="inhibitors">inhibitors</span>, <span word="or">or</span> <span word="P">P</span>.<span word="P">P</span>.<span word="I">I</span>.'<span word="s">s</span> — <span word="gastric">gastric</span> <span word="reflux">reflux</span> <span word="preventives">preventives</span> <span word="like">like</span> <span word="Prilosec">Prilosec</span> <span word="and">and</span> <span word="Prevacid">Prevacid</span> — <span word="may">may</span> <span word="increase">increase</span> <span word="the">the</span> <span word="risk">risk</span> <span word="for">for</span> <span word="heart">heart</span> <span word="attack">attack</span>, <span word="according">according</span> <span word="to">to</span> <span word="analysis">analysis</span> <span word="of">of</span> <span word="data">data</span> <span word="involving">involving</span> <span word="almost">almost</span> <span word="three">three</span> <span word="million">million</span> <span word="people">people</span>.</p><p>一项涉及近300万人的数据的分析显示，目前广泛用于预防胃反流的药物——质子泵抑制剂（<span word="proton">proton</span> <span word="pump">pump</span> <span word="inhibitors">inhibitors</span>, <span word="P">P</span>.<span word="P">P</span>.<span word="I">I</span>.，如奥美拉唑和兰索拉唑等）可能会增加心肌梗死的风险。</p><p><span word="Previous">Previous</span> <span word="studies">studies</span> <span word="have">have</span> <span word="found">found</span> <span word="that">that</span> <span word="P">P</span>.<span word="P">P</span>.<span word="I">I</span>.'<span word="s">s</span> <span word="are">are</span> <span word="associated">associated</span> <span word="with">with</span> <span word="poor">poor</span> <span word="outcomes">outcomes</span> <span word="for">for</span> <span word="people">people</span> <span word="with">with</span> <span word="heart">heart</span> <span word="disease">disease</span>, <span word="probably">probably</span> <span word="because">because</span> <span word="of">of</span> <span word="an">an</span> <span word="interaction">interaction</span> <span word="with">with</span> <span word="clopidogrel">clopidogrel</span>, <span word="a">a</span> <span word="drug">drug</span> <span word="commonly">commonly</span> <span word="prescribed">prescribed</span> <span word="after">after</span> <span word="a">a</span> <span word="heart">heart</span> <span word="attack">attack</span>. <span word="This">This</span> <span word="new">new</span> <span word="study">study</span> <span word="examines">examines</span> <span word="the">the</span> <span word="heart">heart</span> <span word="attack">attack</span> <span word="risk">risk</span> <span word="in">in</span> <span word="otherwise">otherwise</span> <span word="healthy">healthy</span> <span word="people">people</span>.</p><p>既往研究发现，<span word="P">P</span>.<span word="P">P</span>.<span word="I">I</span>.与心脏病患者预后不良相关，这可能是因为它会与心肌梗死后的常用处方药氯吡格雷发生药物相互作用。而上面提到的这项新研究则分析了健康人中的心肌梗死风险。</p><p><span word="The">The</span> <span word="researchers">researchers</span> <span word="used">used</span> <span word="data">data</span>-<span word="mining">mining</span>, <span word="a">a</span> <span word="mathematical">mathematical</span> <span word="method">method</span> <span word="of">of</span> <span word="looking">looking</span> <span word="at">at</span> <span word="trends">trends</span> <span word="in">in</span> <span word="large">large</span> <span word="amounts">amounts</span> <span word="of">of</span> <span word="data">data</span>, <span word="to">to</span> <span word="analyze">analyze</span> <span word="the">the</span> <span word="use">use</span> <span word="of">of</span> <span word="the">the</span> <span word="drugs">drugs</span> <span word="over">over</span> <span word="time">time</span>. <span word="Evidence">Evidence</span> <span word="that">that</span> <span word="they">they</span> <span word="were">were</span> <span word="increasing">increasing</span> <span word="the">the</span> <span word="risk">risk</span> <span word="for">for</span> <span word="heart">heart</span> <span word="attack">attack</span> <span word="was">was</span> <span word="clear">clear</span> <span word="as">as</span> <span word="early">early</span> <span word="as">as</span> 2000.</p><p>研究人员使用了数据挖掘，也就是一种从大量数据中寻找趋势的数学方法来分析药物使用随时间的变化。研究结果表明，早在2000年，这类药物会增加心机梗死风险的证据就已经十分明显。</p>
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