难治的偏头痛让科学家头痛
<p><span word="The">The</span> <span word="hunt">hunt</span> <span word="is">is</span> <span word="intensifying">intensifying</span> <span word="for">for</span> <span word="new">new</span> <span word="treatments">treatments</span> <span word="for">for</span> <span word="migraines">migraines</span>, <span word="the">the</span> <span word="common">common</span> <span word="and">and</span> <span word="debilitating">debilitating</span> <span word="headaches">headaches</span> <span word="that">that</span> <span word="have">have</span> <span word="confounded">confounded</span> <span word="scientists">scientists</span> <span word="for">for</span> <span word="decades">decades</span>.</p><p>人类正在加紧寻求治疗偏头痛的方法，这种让人身体虚弱的常见头痛病已经困扰了科学家数十年。</p><p><span word="Of">Of</span> <span word="greatest">greatest</span> <span word="focus">focus</span> <span word="for">for</span> <span word="researchers">researchers</span> <span word="is">is</span> <span word="a">a</span> <span word="brain">brain</span> <span word="chemical">chemical</span> <span word="known">known</span> <span word="as">as</span> <span word="CGRP">CGRP</span>, <span word="which">which</span> <span word="appears">appears</span> <span word="to">to</span> <span word="play">play</span> <span word="a">a</span> <span word="role">role</span> <span word="in">in</span> <span word="the">the</span> <span word="transmission">transmission</span> <span word="of">of</span> <span word="pain">pain</span>, <span word="but">but</span> <span word="not">not</span> <span word="in">in</span> <span word="other">other</span> <span word="brain">brain</span> <span word="functions">functions</span>, <span word="such">such</span> <span word="as">as</span> <span word="cognition">cognition</span> <span word="or">or</span> <span word="mood">mood</span>. <span word="Researchers">Researchers</span> <span word="are">are</span> <span word="trying">trying</span> <span word="a">a</span> <span word="variety">variety</span> <span word="of">of</span> <span word="experimental">experimental</span> <span word="drugs">drugs</span> <span word="to">to</span> <span word="stop">stop</span> <span word="CGRP">CGRP</span> <span word="from">from</span> <span word="working">working</span> <span word="by">by</span> <span word="blocking">blocking</span> <span word="its">its</span> <span word="receptors">receptors</span> <span word="in">in</span> <span word="the">the</span> <span word="brain">brain</span>. <span word="Others">Others</span> <span word="are">are</span> <span word="working">working</span> <span word="on">on</span> <span word="artificial">artificial</span> <span word="antibodies">antibodies</span> <span word="that">that</span> <span word="could">could</span> <span word="soak">soak</span> <span word="up">up</span> <span word="the">the</span> <span word="chemical">chemical</span> <span word="in">in</span> <span word="the">the</span> <span word="bloodstream">bloodstream</span> <span word="or">or</span> <span word="brain">brain</span> <span word="before">before</span> <span word="it">it</span> <span word="can">can</span> <span word="trigger">trigger</span> <span word="migraines">migraines</span>.</p><p>研究人员关注最多的是一种名为降钙素基因相关口（<span word="CGRP">CGRP</span>）的大脑化学物质，这种物质似乎与痛感传递有关，但是在认知或情绪等大脑的其它功能方面并没有造成影响。研究人员尝试使用各种实验药物，通过屏蔽大脑里感应<span word="CGRP">CGRP</span>的部分来阻止<span word="CGRP">CGRP</span>发生作用。还有一些人正致力于人工抗体的研制，使其在<span word="CGRP">CGRP</span>引发偏头痛之前将血液或大脑中的这种化学物质吸收。</p><p><span word="Experts">Experts</span> <span word="say">say</span> <span word="the">the</span> <span word="need">need</span> <span word="for">for</span> <span word="new">new</span> <span word="medicines">medicines</span> <span word="to">to</span> <span word="treat">treat</span> <span word="migraine">migraine</span> <span word="pain">pain</span> <span word="once">once</span> <span word="it">it</span> <span word="begins">begins</span> <span word="is">is</span> <span word="great">great</span> <span word="because">because</span> <span word="current">current</span> <span word="drugs">drugs</span> <span word="only">only</span> <span word="provide">provide</span> <span word="some">some</span> <span word="benefit">benefit</span> <span word="for">for</span> 50% <span word="to">to</span> 60% <span word="of">of</span> <span word="sufferers">sufferers</span> <span word="and">and</span> <span word="can">can</span>'<span word="t">t</span> <span word="be">be</span> <span word="used">used</span> <span word="in">in</span> <span word="people">people</span> <span word="with">with</span> <span word="heart">heart</span> <span word="disease">disease</span> <span word="or">or</span> <span word="who">who</span> <span word="have">have</span> <span word="had">had</span> <span word="a">a</span> <span word="stroke">stroke</span>. <span word="Also">Also</span>, <span word="they">they</span> <span word="aren">aren</span>'<span word="t">t</span> <span word="a">a</span> <span word="cure">cure</span>, <span word="and">and</span> <span word="in">in</span> <span word="many">many</span> <span word="cases">cases</span>, <span word="the">the</span> <span word="headaches">headaches</span> <span word="tend">tend</span> <span word="to">to</span> <span word="come">come</span> <span word="back">back</span> <span word="within">within</span> 24 <span word="hours">hours</span>.</p>
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