人体发现的蛋白质或能抑制艾滋病病毒
<p><span word="Chinese">Chinese</span> <span word="scientists">scientists</span> <span word="have">have</span> <span word="identified">identified</span> <span word="a">a</span> <span word="new">new</span> <span word="protein">protein</span> <span word="that">that</span> <span word="restricts">restricts</span> <span word="HIV">HIV</span> <span word="infection">infection</span>, <span word="a">a</span> <span word="discovery">discovery</span> <span word="that">that</span> <span word="could">could</span> <span word="pave">pave</span> <span word="the">the</span> <span word="way">way</span> <span word="for">for</span> <span word="the">the</span> <span word="development">development</span> <span word="of">of</span> <span word="new">new</span> <span word="drugs">drugs</span> <span word="against">against</span> <span word="the">the</span> <span word="virus">virus</span>. <span word="The">The</span> <span word="protein">protein</span>, <span word="P">P</span>-<span word="selectin">selectin</span> <span word="glycoprotein">glycoprotein</span> <span word="ligand">ligand</span> 1 (<span word="PSGL">PSGL</span>-1), <span word="which">which</span> <span word="exists">exists</span> <span word="in">in</span> <span word="human">human</span> <span word="cells">cells</span>, <span word="can">can</span> <span word="inhibit">inhibit</span> <span word="the">the</span> <span word="process">process</span> <span word="by">by</span> <span word="which">which</span> <span word="HIV">HIV</span> <span word="replicates">replicates</span>, <span word="according">according</span> <span word="to">to</span> <span word="research">research</span> <span word="published">published</span> <span word="in">in</span> <span word="the">the</span> <span word="science">science</span> <span word="journal">journal</span> <span word="Nature">Nature</span> <span word="Microbiology">Microbiology</span> <span word="this">this</span> <span word="month">month</span>.</p><p>中国科学家新发现了一种可以抑制艾滋病病毒感染的蛋白质，这一发现或为研发抗艾滋病病毒的新药品开辟路径。本月于《自然·微生物学》科学杂志上发表的研究表明，<span word="P">P</span>-选择素糖蛋白配体1（<span word="PSGL">PSGL</span>-1）蛋白质存在于人体细胞，可抑制艾滋病病毒的繁殖过程。</p><p><span word="However">However</span>, <span word="the">the</span> <span word="study">study</span> <span word="also">also</span> <span word="showed">showed</span> <span word="that">that</span> <span word="PSGL">PSGL</span>-1 <span word="can">can</span> <span word="be">be</span> <span word="negatively">negatively</span> <span word="affected">affected</span> <span word="by">by</span> <span word="Vpu">Vpu</span>－<span word="an">an</span> <span word="accessory">accessory</span> <span word="protein">protein</span> <span word="of">of</span> <span word="HIV">HIV</span>－<span word="which">which</span> <span word="can">can</span> <span word="neutralize">neutralize</span> <span word="the">the</span> <span word="ability">ability</span> <span word="of">of</span> <span word="PSGL">PSGL</span>-1 <span word="to">to</span> <span word="resist">resist</span> <span word="HIV">HIV</span>. <span word="Further">Further</span> <span word="research">research</span> <span word="is">is</span> <span word="underway">underway</span> <span word="to">to</span> <span word="develop">develop</span> <span word="a">a</span> <span word="drug">drug</span> <span word="that">that</span> <span word="can">can</span> <span word="inhibit">inhibit</span> <span word="the">the</span> <span word="HIV">HIV</span> <span word="protein">protein</span> <span word="so">so</span> <span word="that">that</span> <span word="PSGL">PSGL</span>-1 <span word="can">can</span> <span word="restrict">restrict</span> <span word="HIV">HIV</span>, <span word="according">according</span> <span word="to">to</span> <span word="Tan">Tan</span> <span word="Xu">Xu</span>, <span word="a">a</span> <span word="researcher">researcher</span> <span word="at">at</span> <span word="Tsinghua">Tsinghua</span> <span word="University">University</span>'<span word="s">s</span> <span word="School">School</span> <span word="of">of</span> <span word="Pharmaceutical">Pharmaceutical</span> <span word="Sciences">Sciences</span>, <span word="a">a</span> <span word="leading">leading</span> <span word="author">author</span> <span word="of">of</span> <span word="the">the</span> <span word="study">study</span>.</p><p>但是，该研究也表明<span word="PSGL">PSGL</span>-1会受到<span word="Vpu">Vpu</span>蛋白（艾滋病病毒的附属蛋白）的负面影响--<span word="Vpu">Vpu</span>会使<span word="PSGL">PSGL</span>-1无法抑制艾滋病病毒。清华大学药学院的研究员、本研究的主要作者谭旭（<span word="Tan">Tan</span> <span word="Xu">Xu</span>）表示，目前正开展进一步的研究以期研发一种可以抑制艾滋病病毒蛋白的药物，使<span word="PSGL">PSGL</span>-1抑制艾滋病病毒。</p>
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