国内英语资讯:Chinese scientists find therapeutic target of common liver cancer
<p><span word="BEIJING">BEIJING</span>, <span word="Feb">Feb</span>. 28-- <span word="Chinese">Chinese</span> <span word="scientists">scientists</span> <span word="have">have</span> <span word="identified">identified</span> <span word="a">a</span> <span word="therapeutic">therapeutic</span> <span word="target">target</span> <span word="of">of</span> <span word="early">early</span>-<span word="stage">stage</span> <span word="hepatocellular">hepatocellular</span> <span word="carcinoma">carcinoma</span> (<span word="HCC">HCC</span>), <span word="the">the</span> <span word="most">most</span> <span word="common">common</span> <span word="type">type</span> <span word="of">of</span> <span word="primary">primary</span> <span word="liver">liver</span> <span word="cancer">cancer</span> <span word="in">in</span> <span word="adults">adults</span>.</p><p><span word="HCC">HCC</span> <span word="is">is</span> <span word="the">the</span> <span word="third">third</span> <span word="leading">leading</span> <span word="cause">cause</span> <span word="of">of</span> <span word="cancer">cancer</span>-<span word="related">related</span> <span word="deaths">deaths</span> <span word="worldwide">worldwide</span>. <span word="Infection">Infection</span> <span word="with">with</span> <span word="the">the</span> <span word="hepatitis">hepatitis</span> <span word="B">B</span> <span word="virus">virus</span> <span word="is">is</span> <span word="one">one</span> <span word="of">of</span> <span word="the">the</span> <span word="leading">leading</span> <span word="risk">risk</span> <span word="factors">factors</span> <span word="for">for</span> <span word="developing">developing</span> <span word="HCC">HCC</span>, <span word="particularly">particularly</span> <span word="in">in</span> <span word="East">East</span> <span word="Asia">Asia</span>, <span word="according">according</span> <span word="to">to</span> <span word="He">He</span> <span word="Fuchu">Fuchu</span>, <span word="chief">chief</span> <span word="scientist">scientist</span> <span word="of">of</span> <span word="the">the</span> <span word="Chinese">Chinese</span> <span word="Human">Human</span> <span word="Proteome">Proteome</span> <span word="Project">Project</span> <span word="and">and</span> <span word="an">an</span> <span word="academician">academician</span> <span word="of">of</span> <span word="the">the</span> <span word="Chinese">Chinese</span> <span word="Academy">Academy</span> <span word="of">of</span> <span word="Sciences">Sciences</span>.</p><p><span word="Although">Although</span> <span word="surgical">surgical</span> <span word="treatment">treatment</span> <span word="may">may</span> <span word="be">be</span> <span word="effective">effective</span> <span word="in">in</span> <span word="the">the</span> <span word="early">early</span> <span word="stages">stages</span>, <span word="the">the</span> <span word="five">five</span>-<span word="year">year</span> <span word="overall">overall</span> <span word="rate">rate</span> <span word="of">of</span> <span word="survival">survival</span> <span word="after">after</span> <span word="developing">developing</span> <span word="this">this</span> <span word="cancer">cancer</span> <span word="is">is</span> <span word="only">only</span> 50 <span word="percent">percent</span> <span word="to">to</span> 70 <span word="percent">percent</span>, <span word="according">according</span> <span word="to">to</span> <span word="scientists">scientists</span>.</p><p><span word="Researchers">Researchers</span> <span word="classified">classified</span> <span word="the">the</span> <span word="cancer">cancer</span> <span word="into">into</span> <span word="three">three</span> <span word="sub">sub</span>-<span word="types">types</span> <span word="S">S</span>-<span word="I">I</span>, <span word="S">S</span>-<span word="II">II</span> <span word="and">and</span> <span word="S">S</span>-<span word="III">III</span>. <span word="Each">Each</span> <span word="of">of</span> <span word="the">the</span> <span word="three">three</span> <span word="sub">sub</span>-<span word="types">types</span> <span word="has">has</span> <span word="a">a</span> <span word="different">different</span> <span word="clinical">clinical</span> <span word="outcome">outcome</span>, <span word="with">with</span> <span word="S">S</span>-<span word="III">III</span> <span word="associated">associated</span> <span word="with">with</span> <span word="the">the</span> <span word="lowest">lowest</span> <span word="overall">overall</span> <span word="rate">rate</span> <span word="of">of</span> <span word="survival">survival</span>.</p><p><span word="By">By</span> <span word="analyzing">analyzing</span> <span word="the">the</span> <span word="proteomic">proteomic</span> <span word="data">data</span> <span word="of">of</span> <span word="the">the</span> <span word="S">S</span>-<span word="III">III</span> <span word="sub">sub</span>-<span word="type">type</span>, <span word="scientists">scientists</span> <span word="found">found</span> <span word="the">the</span> <span word="therapeutic">therapeutic</span> <span word="target">target</span> <span word="called">called</span> <span word="SOAT">SOAT</span>1. <span word="The">The</span> <span word="knockdown">knockdown</span> <span word="of">of</span> <span word="SOAT">SOAT</span>1 <span word="can">can</span> <span word="effectively">effectively</span> <span word="suppress">suppress</span> <span word="the">the</span> <span word="proliferation">proliferation</span> <span word="and">and</span> <span word="migration">migration</span> <span word="of">of</span> <span word="HCC">HCC</span>.</p><p><span word="In">In</span> <span word="experiments">experiments</span> <span word="on">on</span> <span word="mice">mice</span>, <span word="they">they</span> <span word="also">also</span> <span word="found">found</span> <span word="that">that</span> <span word="treatment">treatment</span> <span word="with">with</span> <span word="avasimibe">avasimibe</span>, <span word="an">an</span> <span word="inhibitor">inhibitor</span> <span word="of">of</span> <span word="SOAT">SOAT</span>1, <span word="markedly">markedly</span> <span word="reduced">reduced</span> <span word="the">the</span> <span word="size">size</span> <span word="of">of</span> <span word="tumors">tumors</span> <span word="that">that</span> <span word="had">had</span> <span word="high">high</span> <span word="levels">levels</span> <span word="of">of</span> <span word="SOAT">SOAT</span>1 <span word="expression">expression</span>.</p><p><span word="The">The</span> <span word="study">study</span> <span word="provides">provides</span> <span word="insight">insight</span> <span word="into">into</span> <span word="the">the</span> <span word="tumor">tumor</span> <span word="biology">biology</span> <span word="of">of</span> <span word="this">this</span> <span word="cancer">cancer</span>, <span word="and">and</span> <span word="suggests">suggests</span> <span word="opportunities">opportunities</span> <span word="for">for</span> <span word="personalized">personalized</span> <span word="therapies">therapies</span> <span word="that">that</span> <span word="target">target</span> <span word="it">it</span>, <span word="He">He</span> <span word="said">said</span>.</p><p><span word="The">The</span> <span word="research">research</span> <span word="was">was</span> <span word="published">published</span> <span word="in">in</span> <span word="the">the</span> <span word="latest">latest</span> <span word="issue">issue</span> <span word="of">of</span> <span word="the">the</span> <span word="academic">academic</span> <span word="journal">journal</span> <span word="Nature">Nature</span>.</p>
页:
[1]