Scientists seek HIV vaccine using monkey model
<p><span word="Traditional">Traditional</span> <span word="vaccine">vaccine</span> <span word="methods">methods</span> <span word="have">have</span> <span word="been">been</span> <span word="unsuccessful">unsuccessful</span> <span word="in">in</span> <span word="preventing">preventing</span> <span word="infection">infection</span> <span word="by">by</span> <span word="HIV">HIV</span>, <span word="the">the</span> <span word="virus">virus</span> <span word="that">that</span> <span word="causes">causes</span> <span word="AIDS">AIDS</span>. <span word="New">New</span> <span word="techniques">techniques</span> <span word="are">are</span> <span word="being">being</span> <span word="studied">studied</span> <span word="to">to</span> <span word="boost">boost</span> <span word="antibodies">antibodies</span> <span word="or">or</span> <span word="other">other</span> <span word="parts">parts</span> <span word="of">of</span> <span word="the">the</span> <span word="immune">immune</span> <span word="system">system</span>. <span word="But">But</span> <span word="researchers">researchers</span> <span word="are">are</span> <span word="also">also</span> <span word="working">working</span> <span word="on">on</span> <span word="a">a</span> <span word="method">method</span> <span word="to">to</span> <span word="keep">keep</span> <span word="the">the</span> <span word="immune">immune</span> <span word="system">system</span> <span word="constantly">constantly</span> <span word="on">on</span> <span word="guard">guard</span> <span word="against">against</span> <span word="HIV">HIV</span>.</p><p><span word="There">There</span> <span word="are">are</span> <span word="two">two</span> <span word="traditional">traditional</span> <span word="methods">methods</span> <span word="for">for</span> <span word="creating">creating</span> <span word="a">a</span> <span word="vaccine">vaccine</span>. <span word="One">One</span> <span word="uses">uses</span> <span word="a">a</span> <span word="weakened">weakened</span> <span word="or">or</span> <span word="attenuated">attenuated</span> <span word="version">version</span> <span word="of">of</span> <span word="a">a</span> <span word="live">live</span> <span word="virus">virus</span> <span word="to">to</span> <span word="generate">generate</span> <span word="an">an</span> <span word="immune">immune</span> <span word="response">response</span>. <span word="The">The</span> <span word="other">other</span> <span word="uses">uses</span> <span word="a">a</span> <span word="dead">dead</span> <span word="virus">virus</span>. <span word="Both">Both</span> <span word="methods">methods</span> <span word="are">are</span> <span word="proven">proven</span> <span word="safe">safe</span> <span word="and">and</span> <span word="effective">effective</span>, <span word="except">except</span> <span word="when">when</span> <span word="it">it</span> <span word="comes">comes</span> <span word="to">to</span> <span word="HIV">HIV</span>. <span word="Vaccine">Vaccine</span> <span word="candidates">candidates</span> <span word="using">using</span> <span word="these">these</span> <span word="methods">methods</span> <span word="simply">simply</span> <span word="have">have</span> <span word="not">not</span> <span word="been">been</span> <span word="successful">successful</span> <span word="in">in</span> <span word="people">people</span> <span word="when">when</span> <span word="it">it</span> <span word="comes">comes</span> <span word="to">to</span> <span word="the">the</span> <span word="AIDS">AIDS</span> <span word="virus">virus</span>.</p><p>“<span word="HIV">HIV</span> <span word="has">has</span> <span word="been">been</span> <span word="a">a</span> <span word="very">very</span> <span word="difficult">difficult</span> <span word="target">target</span> <span word="for">for</span> <span word="a">a</span> <span word="vaccine">vaccine</span> <span word="for">for</span> <span word="a">a</span> <span word="variety">variety</span> <span word="of">of</span> <span word="reasons">reasons</span>. <span word="It">It</span>’<span word="s">s</span> <span word="designed">designed</span> <span word="to">to</span> <span word="evade">evade</span> <span word="the">the</span> <span word="immune">immune</span> <span word="response">response</span> <span word="by">by</span> <span word="evolution">evolution</span>,” <span word="said">said</span> <span word="Dr">Dr</span>. <span word="Louis">Louis</span> <span word="Picker">Picker</span>, <span word="associate">associate</span> <span word="director">director</span> <span word="of">of</span> <span word="Oregon">Oregon</span> <span word="Health">Health</span> <span word="and">and</span> <span word="Science">Science</span> <span word="University">University</span>.</p><p><span word="While">While</span> <span word="attempts">attempts</span> <span word="to">to</span> <span word="make">make</span> <span word="an">an</span> <span word="HIV">HIV</span> <span word="vaccine">vaccine</span> <span word="from">from</span> <span word="a">a</span> <span word="dead">dead</span> <span word="virus">virus</span> <span word="have">have</span> <span word="failed">failed</span>, <span word="Picker">Picker</span> <span word="said">said</span>, <span word="using">using</span> <span word="a">a</span> <span word="weakened">weakened</span> <span word="virus">virus</span> <span word="holds">holds</span> <span word="clues">clues</span> <span word="and">and</span> <span word="possibilities">possibilities</span> <span word="when">when</span> <span word="used">used</span> <span word="in">in</span> <span word="primates">primates</span>.</p><p>“<span word="The">The</span> <span word="live">live</span> <span word="attenuated">attenuated</span> <span word="approach">approach</span> <span word="actually">actually</span> <span word="was">was</span> <span word="shown">shown</span> <span word="to">to</span> <span word="work">work</span> 20 <span word="years">years</span> <span word="ago">ago</span>. <span word="But">But</span> <span word="the">the</span> <span word="problem">problem</span> <span word="with">with</span> <span word="it">it</span> <span word="was">was</span> <span word="the">the</span> <span word="live">live</span> <span word="attenuated">attenuated</span> <span word="vaccines">vaccines</span> <span word="that">that</span> <span word="actually">actually</span> <span word="worked">worked</span> <span word="were">were</span> <span word="actually">actually</span> <span word="still">still</span> <span word="pathogenic">pathogenic</span>. <span word="So">So</span> <span word="they">they</span> <span word="weren">weren</span>’<span word="t">t</span> <span word="safe">safe</span> <span word="and">and</span> <span word="they">they</span> <span word="could">could</span> <span word="not">not</span> <span word="be">be</span> <span word="moved">moved</span> <span word="into">into</span> <span word="humans">humans</span>. <span word="This">This</span> <span word="was">was</span> <span word="demonstrated">demonstrated</span> <span word="in">in</span> <span word="the">the</span> <span word="non">non</span>-<span word="human">human</span> <span word="primate">primate</span> <span word="models">models</span> – <span word="monkey">monkey</span> <span word="model">model</span> <span word="of">of</span> <span word="AIDS">AIDS</span> <span word="using">using</span> <span word="the">the</span> <span word="virus">virus</span> <span word="SIV">SIV</span>,” <span word="he">he</span> <span word="said">said</span>.</p><p><span word="SIV">SIV</span> <span word="stands">stands</span> <span word="for">for</span> <span word="simian">simian</span> <span word="immunodeficiency">immunodeficiency</span> <span word="virus">virus</span>.</p>
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